SPG11 polyclonal antibody
产品名称： SPG11 polyclonal antibody
英文名称： SPG11 polyclonal antibody
产品编号： PAB16698
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SPG11.
- Immunogen:
- A synthetic peptide corresponding to 15 amino acids near C-terminus of human SPG11.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Peptide affinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
Immunohistochemistry (2.5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- SPG11 mutations cause Kjellin syndrome, a hereditary spastic paraplegia with thin corpus callosum and central retinal degeneration.
Orlen H, Melberg A, Raininko R, Kumlien E, Entesarian M, Soderberg P, Pahlman M, Darin N, Kyllerman M, Holmberg E, Engler H, Eriksson U, Dahl N.Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):984-92.
- 2.
- Point mutations and a large intragenic deletion in SPG11 in complicated spastic paraplegia without thin corpus callosum.
Crimella C, Arnoldi A, Crippa F, Mostacciuolo ML, Boaretto F, Sironi M, D'Angelo MG, Manzoni S, Piccinini L, Turconi AC, Toscano A, Musumeci O, Benedetti S, Fazio R, Bresolin N, Daga A, Martinuzzi A, Bassi MT.J Med Genet. 2009 May;46(5):345-51. Epub 2009 Feb 5.
- 3.
- SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia.
Paisan-Ruiz C, Dogu O, Yilmaz A, Houlden H, Singleton A.Neurology. 2008 Apr 15;70(16 Pt 2):1384-9. Epub 2008 Mar 12.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of SPG11 in mouse heart tissue lysate with SPG11 polyclonal antibody (Cat # PAB16698) at (A) 0.5 and (B) 1 ug/mL .
- Entrez GeneID:
- 80208
- Protein Accession#:
- AAI53880
- Gene Name:
- SPG11
- Gene Alias:
- DKFZp762B1512,FLJ21439,KIAA1840,SPATACSIN
- Gene Description:
- spastic paraplegia 11 (autosomal recessive)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
- Other Designations:
- -
- Related Disease