DPABH-25139 detects endogenous levels of SHP1 only when phosphorylated at tyrosine 536.Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.Store at -20°C. Stable for 12 months at -20°C *   http://www.creative-diagnostics.com/Anti-PTPN6-PAb-197951-489.htm